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張家源

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助理教授
姓名 張家源 (Chia-Yuan Chang)
組別 固體力學組
教授室 91712室
分機 62161
傳真機
電子信箱 cychang0829@gmail.com
個人網站
學歷
  1. 國立成功大學 光電科學與工程學系 博士 (2010-2014)
  2. 國立成功大學 光電科學與工程研究所 碩士 (2008-2010)
  3. 國立成功大學 工程科學系 學士 (2004-2008)
經歷
  1. 國立成功大學機械工程學系助理教授(2019-)
  2. 國立成功大學尖端光電中心助理研究員(2017-2019)
  3. 國立成功大學微奈米科技研究中心博士後研究員(2015-2016)
  4. 美國哈佛大學醫學院與麻州總醫院參訪學者(2013-2014)
專長
  1. 非線性光學顯微術
  2. 適應性光學
  3. 光電系統整合開發
教師研究介紹
服務
榮譽
專利
著作

國際期刊論文:

  1. C.-H. Lien, C.-Y. Lin, C.-Y. Chang, and F.-C. Chien, “A Simulation Design of Wide-Field Temporal- Focusing Multiphoton Excitation with Tunable Excitation Wavelength,” OSA Continuum2(4), 1174–1187 (2019).
  2. S.-F. Tsai, C.-Y. Chang, S.-M. Yong, Ai-L. Lim, Y. Nakao, S.-J. Chen, and Yu-M. Kuo, “A Hydrolyzed Chicken Extract CMI-168 Enhances Learning and Memory in Middle-Aged Mice,” Nutrients11(1), 27 (2019).
  3. W.-T. Huang, I.-W. Chong, H.-L. Chen, C.-Y. Li, C.-C. Hsieh, H.-F. Kuo, C.-Y. Chang, Y.-H. Chen, Y.-P. Liu, C.-Y. Lu, Y.-R. Liu, Po-L. Liu, “Pigment epithelium-derived factor inhibits lung cancer migration and Tinvasion by upregulating exosomal thrombospondin 1,” Cancer Lett.442, 287–298 (2019).
  4. Y. D. Sie, C.-Y. Chang, C.-Y. Lin, N.-S. Chang, P. J. Campagnola, and S.-J. Chen, “Fast and improved bioimaging via temporal focusing multiphoton excitation microscopy with binary digital-micromirror-device holography,” J. Biomed. Opt. 23(11), 116502 (2018).
  5. C.-Y. Chang, C.-H. Lin, C.-Y. Lin, Y.-D. Sie, Y. Y. Hu, S.-F. Tsai, and S.-J. Chen, “Temporal focusing-based widefield multiphoton microscopy with spatially modulated illumination for biotissue imaging,” J. Biophotonics 11(1), e201600287 (2018).
  6. P.-C. Wu, J.-Y. Wang, W.-L. Wang, C.-Y. Chang, C.-H. Huang, K.-L. Yang, J.-C. Chang, C.-L. L. Hsu, S.-Y. Chen, T.-M. Chou, and W.-S. Kuo, “Efficient Two-Photon Luminescence for Cellular Imaging Using Biocompatible Nitrogen-doped Graphene quantum Dots Conjugated with Polymers,” Nanoscale 10(1), 109–117 (2018).
  7. W.-S. Kuo, H.-H. Chen, S.-Y. Chen, C.-Y. Chang, C.-L. L. Hsu, H.-F. Kao, Y.-C. Chen, S.-J. Chen, W.-T. Chang, S.-R. Wu, J.-Y. Wang, “Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging,” Biomaterials120, 185–194 (2017).
  8. W.-S. Kuo, C.-Y. Chang, H.-H. Chen, C.-L. L. Hsu, J.-Y. Wang, H.-F. Kao, L. C.-S. Chou, Y.-C. Chen, S.-J. Chen, W.-T. Chang, S.-W. Tseng, P.-C. Wu, and Y.-C. Pu, “Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots,” ACS Appl. Mater. Interfaces8(44), 30467–30474 (2016). (Equal contribution)
  9. W.-S. Kuo, C.-L. L. Hsu, H.-H. Chen, C.-Y. Chang, H.-F. Kao, L. C.-S. Chou, Y.-C. Chen, S.-J. Chen, W.-T. Chang, S.-W. Tseng, J.-Y. Wang, and Y.-C. Pu, “Graphene quantum dots conjugated with polymers for two-photon properties under two-photon excitation,” Nanoscale8(38), 16874–16880 (2016).
  10. H.-Y. Chang, C.-Y. Lin, C.-Y. Chang, H. Teng, P. J. Campagnola, and S.-J. Chen, “Graphene oxide dot-based microstructures via dispersion and support of bovine serum albumin,” Opt. Mater. Express6(10), 3193–3201 (2016).
  11. C.-Y. Chang, Y. Y. Hu, C.-Y. Lin, C.-H. Lin, H.-Y. Chang, S.-F. Tsai, T.-W. Lin, and S.-J. Chen, “Fast volumetric imaging with patterned illumination via digital micro-mirror device-based temporal focusing multiphoton microscopy,” Biomed. Opt. Express7(5), 1727–1736 (2016).
  12. W.-T. Chang, S.-J. Chen, C.-Y. Chang, Y.-H. Liu, C.-H. Chen, C.-H. Yang, L. C.-S. Chou, J.-C. Chang, L.-C. Cheng, W.-S. Kuo, and J.-Y. Wang, “Effect of size-dependent photodestructive efficacy by gold nanomaterials with multiphoton laser,” ACS Appl. Mater. Interfaces7(31), 17318–17329 (2015). (Equal contribution)
  13. T.-W. Lin, Y.-F. Liu, Y.-H. Shih, S.-J. Chen, T.-Y. Huang, C.-Y. Chang, C.-H. Lien, L. Yu, S.-H. Chen, and Y.-M. Kuo, “Neurodegeneration in Amygdala Precedes Hippocampus in the APPswe/ PS1dE9 Mouse Model of Alzheimer’s Disease,” Curr. Alzheimer. Res.12(10), 951–963 (2015).
  14. C.-Y. Lin, P.-K. Li, L.-C. Cheng, Y.-C. Li, C.-Y. Chang, A.-S. Chiang, C. Y. Dong, and S.-J. Chen, “High-throughput multiphoton-induced three-dimensional ablation and imaging for biotissues,” Biomed. Opt. Express6(2), 491–499 (2015).
  15. T.-W. Lin, Y.-H. Shih, S.-J. Chen, C.-H. Lien,C.-Y. Chang, T.-Y. Huang, S.-H. Chen, C. J. Jen, and Y.-M. Kuo, “Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer’s disease (APP/PS1) transgenic mice,” Neurobiol. Learn. Mem.118, 189–197 (2015).
  16. Y.-C. Li, T.-F. Yeh, H.-C. Huang, H.-Y. Chang, C.-Y. Lin, L.-C. Cheng, C.-Y. Chang, H. Teng, and S.-J. Chen, “Graphene oxide-based micropatterns via high-throughput multiphoton-induced reduction and ablation,” Opt. Express22(16), 19726–19734 (2014).
  17. C.-Y. Chang, L.-C. Cheng, H.-W. Su, Y. Y. Hu, K.-C. Cho, W.-C. Yen, C. Xu, C. Y. Dong, and S.-J. Chen, “Wavefront sensorless adaptive optics temporal focusing-based multiphoton microscopy,” Biomed. Opt. Express5(6), 1768–1777 (2014).
  18. S.-F. Tsai, T.-Y. Huang, C.-Y. Chang, Y.-C. Hsu, S.-J. Chen, L. Yu, Y.-M. Kuo, and C. J. Jen, “Social instability stress differentially affects amygdalar neuron adaptations and memory performance in adolescent and adult rats,” Front. Behav. Neurosci.8(27), 1–8 (2014).
  19. C.-Y. Chang, B.-T. Ke, H.-W. Su, W.-C. Yen, and S.-J. Chen, “Easily implementable field programmable gate array-based adaptive optics system with state-space multichannel control,” Rev. Sci. Instrum.84(9), 095112 (2013).
  20. Y.-C. Li, L.-C. Cheng, C.-Y. Chang, C.-Y. Lin, N.-S. Chang, P. J. Campagnola, C. Y. Dong, and S.-J. Chen, “High-throughput fabrication of gray-level biomicrostructures via temporal focusing excitation and laser pulse control,” J. Biomed. Opt.18(7), 075004 (2013).
  21. Y.-C. Li, L.-C. Cheng, C.-Y. Chang, C.-H. Lien, P. J. Campagnola, and S.-J. Chen, “Fast multiphoton microfabrication of freeform polymer microstructures by spatiotemporal focusing and patterned excitation,” Opt. Express20(17), 19030–19038 (2012).
  22. C.-Y. Lin, C.-H. Lien, K.-C. Cho, C.-Y. Chang, N.-S. Chang, P. J. Campagnola, C. Y. Dong, and S.-J. Chen, “Investigation of two-photon excited fluorescence increment via crosslinked bovine serum albumin,” Opt Express20(13), 13669–13676 (2012).
  23. L.-C. Cheng, C.-Y. Chang, C.-Y. Lin, K.-C. Cho, W.-C. Yen, N.-S. Chang, C. Xu, C. Y. Dong, and S.-J. Chen, “Spatiotemporal focusing-based widefield multiphoton microscopy for fast optical sectioning,” Opt Express20(8), 8939–8948 (2012).
  24. T.-W. Lin, S.-J. Chen, T.-Y. Huang, C.-Y. Chang, J.-I. Chuang, F.-S. Wu, Y.-M. Kuo, and C. J. Jen, “Different types of exercise induce differential effects on neuronal adaptations and memory performance,” Neurobiol. Learn. Mem.97(1), 140–147 (2012).
  25. K.-C. Cho, C.-H. Lien, C.-Y. Lin, C.-Y. Chang, L. L. H. Huang, P. J. Campagnola, C. Y. Dong, and S.-J. Chen, “Enhanced two-photon excited fluorescence in three-dimensionally crosslinked bovine serum albumin microstructures,” Opt Express19(12), 11732–11739 (2011).
  26. W.-S. Kuo, C.-H. Lien, K.-C. Cho, C.-Y. Chang, C.-Y. Lin, L. L. H. Huang, P. J. Campagnola, C. Y. Dong, and S.-J. Chen, “Multiphoton fabrication of freeform polymer microstructures with gold nanorods,” Opt. Express18(26), 27550–27559 (2010).
  27. C.-Y. Lin, K.-C. Chiu, C.-Y. Chang, S.-H. Chang, T.-F. Guo, and S.-J. Chen, “Surface plasmon-enhanced and quenched two-photon excited fluorescence,” Opt. Express18(12), 12807–12817 (2010)

國際研討會:

  1. Yu S. Hsu, C. W. Hsu, J. L. Hsieh, C. Y. Wu, C. Yu Lin, C. Y. Chang, S. J. Chen, “Rapid 3D Multiphoton Excitation Microscope with the Combination of a Resonant Mirror and an Ultrasound Lens,” International Conference on Optics and Photonics Taiwan (2018).
  2. F.-C. Hsu, Y. Da Sie, C.-Y. Chang, Y. Y. Hu, I-H. Gau, S.-J. Chen,”Fast Volumetric Bioimaging via Light Field Microscopy with Selective Temporal Focusing Volume Illumination,” International Conference on Optics and Photonics Taiwan (2018).
  3. Y.-S. Chen, S.-J. Hsieh, C.-Y. Chang, S.-J. Chen, C.-C. Lin, C.-H. Chen, “Optical Devices for Pre-Collimating and Guiding Edge-Emitting Laser Diodes via Multiphoton Microfabrication,” International Conference on Optics and Photonics Taiwan (2018).
  4. J.-L. Hsieh, Y.-P. Chen, Y.-C. Chang, C.-Y. Chang, and S.-J. Chen, “Rapid Shack-Hartmann Wavefront Sensor for Adaptive Optics System via FPGA-embedded Camera Link,” International Conference on Optics and Photonics Taiwan (2018). OPTIC 2018 Student Paper Award
  5. C.-Y. Chang, C.-Y. Lin, and S.-J. Chen, “Multi-line Scanning-based Temporal Focusing Multiphoton Microscopy,” International Conference on Optics and Photonics Taiwan (2018).
  6. C.-Y. Chang, S.-J. Chen, F.-C. Hsu, Y.-S. Hsu, Z.-C. Huang, “High-Speed Optoelectronic Signal Converter for Fluorescence Microscopy,” International Conference on Optics and Photonics Taiwan (2018).
  7. Y.-P. Chen, C.-Y. Chang, and S.-J. Chen, “Rapid and highly integrated FPGA-based Shack-Hartmann wavefront sensor for adaptive optics system,” Proc. SPIE 10502, 1050203 (2018).
  8. Y.-P. Chen, C.-Y. Chang, and S.-J. Chen, “Rapid and Highly Integrated FPGA-based Shack-Hartmann Wavefront Sensor for Adaptive Optics System,” International Conference on Optics and Photonics Taiwan (2017). OPTIC 2017 Student Paper Award
  9. C.-Y. Chang and S.-J. Chen, “Improvement of axial excitation confinement in temporal focusing-based multiphoton microscopy via spatially modulated illumination,” Proc. SPIE 10117, 101170F (2017).
  10. C.-Y. Chang, Y. Y. Hu, C.-Y. Lin, and S.-J. Chen, “Fast volumetric imaging and patterned illumination via DMD-based temporal focusing multiphoton microscopy,” The 9th International Conference on Nanophotonics (2016).
  11. C.-Y. Chang, T.-W. Lin, C.-Y. Lin, L.-C. Cheng, Y.-C. Li, and S.-J. Chen, “Functional Widefield Multiphoton Microscopy,” OSA Optics in the Life Sciences (2015).
  12. C.-Y. Chang, L.-C. Cheng, and S.-J. Chen, “Wavefront Sensorless Adaptive Optics in Temporal Focusing Multiphoton Microscopy,” International Conference on Optics and Photonics Taiwan (2014).
  13. Y.-C. Li, L.-C. Cheng, C.-H. Lien, C.-Y. Chang, W.-C. Yen, and S.-J. Chen, “Fast multiphoton microfabrication of freeform polymer microstructures by spatiotemporal focusing and patterned generation,” Proc. SPIE 8489, 848905 (2012).
  14. C.-Y. Chang, L.-C. Cheng, H.-W. Su, W.-C. Yen, S.-J. Chen, “Widefield multiphoton microscopy with image-based adaptive optics,” Proc. SPIE 8520, 85200O (2012).
  15. L.-C. Cheng, C.-Y. Chang, W.-C. Yen, S.-J. Chen, “Spatiotemporal focusing-based widefield multiphoton microscopy for fast optical sectioning of thick tissues,” Proc. SPIE 8520, 85200N (2012).
  16. C.-Y. Lin, C.-H. Lien, K.-C. Chiu, C.-Y. Chang, S.-H. Chang, T.-F. Guo, S.-J. Chen, “Surface plasmon-enhanced and quenched two-photon excited fluorescence,” Proc. SPIE 7757, 77573A (2010).

其他著作:

  1. 鄭力中,張家源,林俊佑,李益誠,連啟翔,胡瑜凌,陳顯禎,〈時域聚焦之多光子激發顯微術〉,《科儀新知200期特刊》第200期,頁66–76,2014。
  2. 鄭力中,張家源,陳顯禎,〈基於空間時域聚焦的廣視域多光子顯微術於快速光學切片上應用〉,《光學工程》第118期,頁33–40,2012。